List Of Publications

1.             N. Mishra, A. Basu, V. Jayaprakash, Ashoke Sharon, M. Basu. Structure Based Virtual Screening of GSK - 3β: Importance of protein flexibility and induced fit. Bioorg. Med. Chem. Lett. 2009, 19, 5582-5.

2.             A. Jha, Ashoke Sharon, C. K. Chu Tetrahedron, 2009, 65, 9362-7.

3.             H. Kim, Ashoke Sharon, C. Bal, J. Wang, M. Allu, Z. Huang, M. G. Murray, L. Bassit, R. F. Schinazi, B. Korba and C. K. Chu Synthesis, Anti-Hepatitis B Virus and Anti-Hepatitis C Virus Activities of     7-Deazaneplanocin A Analogues In Vitro. J. Med. Chem. 2009, 52, 206-213.

4.             Y. Liang, Ashoke Sharon, J. P. Grier, K. L. Rapp, R. F. Schinazi and C. K. Chu 5'-O-Aliphatic and amino acid ester prodrugs of (-)-β-D-(2R,4R)-dioxolane-thymine (DOT): Synthesis, anti-HIV activity, cytotoxicity and stability studies. Bioorg. Med. Chem. 2009, 17, 1404-1409.

5.             Ashoke Sharon, C. K. Chu. Molecular Basis of Drug Resistance of Anti-Hepatitis B Virus Agents by Molecular Modeling. Antiviral Research 2008,80, 339-353.

6.             P. Liu, Ashoke Sharon, C. K. Chu Fluorinated Nucleosides: Synthesis and Biological Implication. Journal of Fluorine Chemistry 2008, 129, 743-766.

7.             Y. Kim, Ashoke Sharon, C. K. Chu, R. H. Rais, O. N. Al Safarjalani, F. N. M. Naguib,  M. H. el Kouni. Structure-Activity Relationships of 7-Deaza-6-benzylthioinosine Analogues as Ligands of Toxoplasma gondii Adenosine Kinase. J. Med. Chem. 2008. 51, 3934-45.

8.             J. Narayanasamy, M. R. Pullarurla, Ashoke Sharon, J. Wang, R. F. Schinazi, C. K. Chu. Synthesis and anti-HIV activity of (-)-β-D-(2R,4R) 1,3-dioxolane 2,6-diamino purine (DAPD) (Amdoxovir-AMDX) and (-)-β-D-(2R,4R) 1,3-dioxolane guanosine (DXG) prodrugs. Antiviral Research 2007, 75, 198-209.

9.             Y. Kim, Ashoke Sharon, R. H. Rais, F. N. M. Naguib, M. H. el Kouni, C. K. Chu, Synthesis, Biological Evaluation and Molecular Modeling Studies of N6-Substituted Adenosine Analogues as Potential Anti-Toxoplasma Agents. Biochemical Pharmacology, 2007, 73, 1558-1572.

10.          P. Liu, Ashoke Sharon, C. K. Chu, Enantiomeric synthesis of carbocyclic D-4'-C-methyl-ribonucleosides as potential antiviral agents. Tetrahedron Asymm., 2006, 17, 3304-3314.

11.          M. Dixit, Ashoke Sharon, P. R. Maulik, A. Goel. A Controlled Synthesis of Nature-Mimicking Benzofurans and their Corresponding Dimers [1]. Synlett 2006, 1497-1502

12.          F. V. Singh, R. Kumar, Ashoke Sharon, C. K. Broder, J. A. K. Howard, A. Goel, P. R. Maulik. Synthesis and X-ray structural studies of pyrimidin-2,4-dione and 2-thioxo-1H-pyrimidin-4-one bearing chloroethyl moiety. Journal of Molecular Structure, 2006, 782, 55-59.

13.          D. Sil, R. Kumar, Ashoke Sharon, P. R. Maulik, V. J. Ram, Stereoselective alkenylation of a 1, 3-disubstituted pyrazol-5-one through ring transformation of 2H-pyran-2-ones.Tetrahedron Letters 2005, 46, (22), 3807-3809.

14.          Ashoke Sharon, R. Pratap, P. Tewari, A. Srivastava, P. R. Maulik, V. J. Ram Synthesis and in vivo antihyperglycemic activity of 5-(1H-Pyrazol-3-yl)methyl-1H-tetrazoles. Bioorg. Med. Chem. Lett. 2005, 15. 2115-2117.

15.          Ashoke Sharon, R. Pratap, R. Vatsyayan, U. Roy, P. R. Maulik, A. Goel, V. J. Ram 6-Aryl-4-methylsulfanyl-2H-pyran-2-one-3-carbonitriles as PPAR-γ activators. Bioorg. Med. Chem. Lett. 2005, 15, 3356-3360.

16.          A. Goel, F. V. Singh, Ashoke Sharon, P. R. Maulik Regioselective Syntheses of Functionalized 2-Aminopyridines and 2-Pyridinones through Nucleophile-Induced Ring Transformation Reactions. Synlett, 2005, 623-626.

17.          Ashoke Sharon, R. Pratap, P. R. Maulik, V. J. Ram,  Synthesis of annelated [a]aza-anthracenones and thieno[3,2-g]aza-naphthalenones through ring transformation of 2H-pyran-2-one followed by photocyclization. Tetrahedron. 2005, 61, 3781–3787.

18.          Ashoke Sharon, R. Pratap, B. Tripathi, A. K. Srivastava, P. R. Maulik, V. J. Ram, Biaryls and heterobiaryls as α-glucosidase and protein tyrosine phosphatase inhibitors. Bioorg. Med. Chem. Lett. 2005, 15 1341-1344.

19.          R. Pratap, Ashoke Sharon, P. R. Maulik, V. J. Ram, An one pot synthesis of annelated [a]aza-thieno[3,2-g]naphthalenone through ring transformation followed by photocyclization. Tetrahedron Lett. 2005, 46, 85-87.

20.          D. Sil, Ashoke Sharon, P. R. Maulik, V. J. Ram One-pot synthesis of cyclopentadienones through ring contraction of 2H-pyran-2-one. Tetrahedron Lett. 2004, 45, 6619-6621.

21.          D. Sil, Ashoke Sharon, R. Pratap, P. R. Maulik, V. J. Ram  Synthesis of benzocyclobutanes through ring transformation reactions of 2H-pyran-2-ones. Synlett. 2004, 12, 2163-2164.

22.          D. Sil, Ashoke Sharon, P. R. Maulik, V. J. Ram, A concise synthesis of highly functionalized a,b-unsaturated g-butyrolactones through ring contraction of 2H-pyran-2-ones. Tetrahedron Lett. 2004, 45, 6273-6276.

23.          Ashoke Sharon, P. R. Maulik, R. Roy, V. J. Ram, An innovative approach to the synthesis of annelated [a]diaza-anthracenones through tandem cyclization. Tetrahedron Lett. 2004, 45, 5815-5818.

24.          Farhanullah, Ashoke Sharon, P. R. Maulik and V. J. Ram, Amberlist 15 catalyzed synthesis of indole-pyrazole based tri(hetero)arylmethanes. Tetrahedron Lett. 2004, 45, 5099-5102.

25.          A. Goel, N. Agarwal, F. V. Singh, Ashoke Sharon, P. Tiwari, M. Dixit, R. Pratap, A. K. Srivastava, P. R. Maulik, V. J. Ram, Antihyperglycemic activity of 2-methyl-3,4,5-triaryl-1H-pyrroles in SLM and STZ model. Bioorg. Med. Chem. Lett. 2004, 14 1089–1092.

26.          Ashoke Sharon, P. R. Maulik, C. Vithana, Y. Ohashi, V. J. Ram, Synthesis of Biphenanthrenyls and Role of C-H…X Noncovalent Interactions in Conformational Control. Eur. J. Org. Chem. 2004, 886-893.

27.          T. R. S. Kumar, P. R. Maulik, S. Srivastava, A. Garh, Ashoke Sharon, A. S. Negi, S. P. S. Khanuja, Absolute Configuration and Anticancer Activity of Taxiresinol and related Lignans of Taxus wallichiana. S. K. Chattopadhyay,Bioorg. Med. Chem. 2003, 11, 4945-4948.

28.          S. Sarkhel, Ashoke Sharon, V. Trivedi, P. R. Maulik, M. M. Singh, P. Venugopalan, S. Ray, Structure-Based Drug Design: Synthesis, Crystal Structure, Biological Evaluation and Docking Studies for Mono- and Bis-benzo[b]oxepines as non-steroidal estrogens. Bioorg. Med. Chem. 2003, 11, 5025-5033.

29.          K. Avasthi, S. M. Farooq, D. S. Rawat,  Ashoke Sharon, P. R. Maulik, A stacked pyrazolo[3,4-d]pyrimidine based flexible molecule: the effect on stacking of an bulky iso-propyl group in comparison with methyl/ethyl group. Acta Cryst., 2003, C59, o523-o524.

30.          Ashoke Sharon, T. Srivastava, S. B. Katti and P. R. Maulik, 2-(4-Chlorophenyl)-3-cyclohexylthiazolidin-4-one. Acta Cryst. 2003, E59, o1239-o1240.

31.          K. Avasthi, C. Bal, Ashoke Sharon, P. R. Maulik, 4,6-Bis-(methylsulfanyl)-1-(4-phenoxybutyl)-1H-pyrazolo[3,4-d]pyrimidine. Acta. Cryst. 2003, C59, o-494-o495.

32.          K. Avasthi, S. M. Farooq, A. K. Tewari, Ashoke Sharon, P. R. Maulik Intermolecular stacking in pyrazolo[3,4-d]pyrimidine-based pentamethylene-linked flexible molecules. Acta. Cryst. 2003, C59, o42-o45.

33.          K. Avasthi, D. Bhagat, C. Bal, Ashoke Sharon, U. Yadav, P. R. Maulik, Unusual molecular conformation in dissymmetric propylene-linker compounds containing pyrazolo-[3,4-d]pyrimidinyl and phthalimido moieties. Acta Cryst. 2003, C59, o409-o412.

34.          K. Avasthi, S. M. Farooq, Ashoke Sharon, P. R. Maulik, Disappearance of inter- and intramolecular stacking due to one-atom addition in ‘propylene linker’ in pyrazolo [3,4-d]pyrimidine-based flexible molecule. Acta. Cryst. 2002, E58, o940-o941. 

35.          V. K. Tandon, Ashoke Sharon, R. Bandichhor, P. R. Maulik,  1,4-Dichloro-1,4-diphenyl-2,3-diazabuta-1,3-diene. Acta. Cryst. 2002, E58, o869-870.

36.          K. Avasthi, A. Tewari, D. S. Rawat, Ashoke Sharon, P. R. Maulik, A stacked pyrazolo[3,4-d]pyrimidine-based flexible molecule: the effect of a bulky benzyl group on intermolecular stacking in comparison with methyl and ethyl groups. Acta. Cryst. 2002, C58, o494-o495.

37.          K. Avasthi, D. S. Rawat, T. Chandra, Ashoke Sharon, P. R. Maulik, Isomeric pyrazolo[3,4-d]pyrimidine-based molecules: Disappearance of dimerization due to interchanged substitutions. Acta Cryst. 2002, C58, o311-o313.

38.          V. J. Ram, N. Agarwal, A. S. Saxena, Farhanullah, Ashoke Sharon, P. R. Maulik, Carbanion induced synthesis of annulated unsymmetrical biaryls through ring transformation of 2H-pyran-2-one. J. Chem. Soc. Perkin Trans. 1 2002, 1426-1437.

39.          V. J. Ram, N. Agarwal, Ashoke Sharon, P. R. Maulik, An expeditious synthesis of imidazo[1,2-a]pyridines through nucleophile induced ring transformation reactions of 6-aryl-4-methylsulfanyl-2H-pyran-2-one-3-carbonitriles. Tetrahedron Lett. 2002, 43, 307-310.

40.          S. K. Chattopadhyay, Ashoke Sharon, U. Yadav, S. Srivastava, V. K. Mehta, P. R. Maulik, A taxane diterpenoid from the heartwood of Taxus wallichiana. Acta. Cryst. 2002, E58, o154-o155.

41.          P. R. Maulik, K. Avasthi, S. Sarkhel, Ashoke Sharon, D. S. Rawat, C. Bal, 1,3-Bis(8-chlorotheophyllin-7-yl)propane: a molecule with no intramolecular stacking. Acta. Cryst. 2001, E57, o1163-o1165.

42.          S. K. Chattopadhyay, Ashoke Sharon, U. Yadav, S. Srivastava, V. K. Mehta, P. R. Maulik, A taxane diterpenoid from the needles of Taxus wallichiana. Acta. Cryst. 2001, E57, o11 o1158-o1160.

43.          V. J. Ram, P. Srivastava, N. Agarwal, Ashoke Sharon, P. R. Maulik, One-pot synthesis of unsymmetical biaryls from suitably functionalized 2H-pyran-2-ones through carbanion induced ring-transformation reactions. J. Chem. Soc. Perkin Trans. 1 2001, 1953-1959.

a.     Books

1. Ashoke Sharon, A. Jha, C. K. Chu. “Clevudine (L-FMAU): A Unique Antiviral Agent for the Treatment of Chronic Hepatitis B Virus (HBV) Infection” Accepted, Analogues Based Drug Discovery, Publisher: IUPAC (International Union of Pure and Applied Chemistry).

b.     Proceedings:

1. Ashoke Sharon, C. K. Chu Clevudine (L-FMAU): A Unique Antiviral Agent for the Treatment of Chronic Hepatitis B Virus Infection. In XIVth Symposium on Chemistry of Nucleic Acid Component, Cesky Krumlov, Czech Republic, In proceedings; 2008.

c.      Invited Lectures/Short-term Course(s) Attended/Participated/Organized

• 1. Dr. Ashoke Sharon, Invited Lecture, Title: “A Structure-Based Approach towards Antiviral Drug Discovery” at CDRI (Central Drug Research Institute, Lucknow), June 2, 2009.

  2. Dr. Ashoke Sharon, Academic Coordinator, Computer Aided Molecular Modeling and Design Lab (CAMMD Lab), AICTE Sponsored Quality Improvement Program (QIP), Drug Discovery Approaches, Department of Pharmaceutical Sciences, BIT Mesra, May 4-May 16, 2009.

  3. Dr. Ashoke Sharon, Invited Lecture, Title: “Structure-Based Drug Design: A rational approach for Drug Discovery” AICTE Sponsored Quality Improvement Program (QIP), Drug Discovery Approaches, Department of Pharmaceutical Sciences, BIT Mesra, May 6, 2009.

  4. Dr. Ashoke Sharon, Invited Lecture, Title: “HepDirect and Prodrug Approaches for Site Selective Drug Delivery” AICTE Sponsored Quality Improvement Program (QIP), Drug Discovery Approaches, Department of Pharmaceutical Sciences, BIT Mesra, May 6, 2009. 

  5. Dr. Ashoke Sharon, Invited Lecture, Title: “Drug Discovery  as Lucrative Career : Global opportunities” 'Current R & D Status and career opportunities In Biotechnology: study scope and objectives' organized by Association of Microbiologist of India, Ranchi Unit, Dept. of Biotechnology, BIT Mesra, Sep, 05, 2009.