Publications

Patents (# 3) :

1. Novel pyranone carboxamide derivative and use thereof as Anti-Hepatitis C Virus drug, Masanori Baba, Ashoke Sharon, Chandralata Bal, and Ananda K Konreddy; Publication No: WO/2015/008779, Application No: PCT/JP2014/068880, Priority Date: July 17, 2013. Publication Date: Jan 22 2015.https://patentscope.wipo.int/search/en/detail.jsf?docId=WO2015008779

2. Anti-hepatitis B virus drugs, Masanori Baba, Takayuki Hamazaki, Ashoke Sharon, Chandralata Bal, Anandarajan Thiyagrajan and Mohan Kasula, Japanese Patent Application number: JP 2013-254236, Filing date: Dec. 9, 2013. [publication number: JP 2015-113285 (P2015-113285A) [publication date] June 22, 2015. http://ipforce.jp/patent-jp-A-2015-113285

3. Anti-hepatitis B virus drugs, Masanori Baba, Takayuki Hamazaki, Ashoke Sharon, Chandralata Bal, Anandarajan Thiyagrajan and Mohan Kasula, Japanese Patent Application number: JP 2013-254238, Filing date: Dec. 9, 2013; [publication number: JP 2015-113286 (P2015-113286A) [publication date] June 22, 2015. http://ipforce.jp/patent-jp-A-2015-113286

Books/Books Chapter (# 3):

1. Ashoke Sharon, A. Jha, C. K. Chu. “Clevudine (L-FMAU): A Unique Antiviral Agent for the Treatment of Chronic Hepatitis B Virus (HBV) Infection” Chapter-16, Analogue-based Drug Discovery II, ISBN: 978-3-527-32549-8, Publisher: Wiley-VCH.

2. Gautam Sen, Ashoke Sharon, Sagar Pal. “Grafted Polysaccharides: Smart Materials of the Future. Their Synthesis and Applications”(Chapter-5) Biopolymers: Biomedical and Environmental Applications, ISBN: 978-0-470-63923-8, Publisher: Wiley - Scrivener Publishing.

(Total Publication # 81) 

Recent Publication:

• 2019

1. Ansari, A. J.; Wani, A. A.; Maurya, A. K.; Verma, S.; Agnihotri, V. K.; Sharon, A.; Bharatam, P. V.; Sawant, D. M., An unprecedented N- to C-sulfonyl migration in the reaction of azomethine amine and allenoates: access to arylsulfonylmethyl substituted pyrazolo[1,5-c]quinazoline and mechanistic studies. Chemical Communications 2019.

2. Rozy, F.; Sharon, A., Base Catalyzed Scaffold Shift from Pyranone Carboxamide to Pyrazolyl Acetamide through Intramolecular Ring Transformation. ChemistrySelect 2019, 4 (20), 6194-6197

3.  Trivedi, J.; Parveen, A.; Rozy, F.; Mitra, A.; Bal, C.; Mitra, D.; Sharon, A., Discovery of 2-isoxazol-3-yl-acetamide analogues as heat shock protein 90 (HSP90) inhibitors with significant anti-HIV activity. European Journal of Medicinal Chemistry 2019, 183, 111699.

4. H. Chakravarty, C. Bal, M. Yadav, N. Jena, N.C. Bal, A. Sharon, First Insight on Small Molecules as Cardiac Calsequestrin Stabilizers, ACS Omega, 2019, 4, 11508-11514.

• 2018

1. Joshi, G.; Chauhan, M.; Kumar, R.; Thakur, A.; Sharma, S.; Singh, R.; Wani, A. A.; Sharon, A.; Bharatam, P. V.; Kumar, R., Cyclocondensation reactions of an electron deactivated 2-aminophenyl tethered imidazole with mono/1,2-biselectrophiles: synthesis and DFT studies on the rationalisation of imidazo[1,2-a]quinoxaline versus benzo[f]imidazo[1,5-a][1,3,5]triazepine selectivity switches. Organic Chemistry Frontiers 2018, 5 (24), 3526-3533. DOI: https://doi.org/10.1039/C8QO00706C 

2. Kundu, S.; Kumari, N.; Soni, S. R.; Ranjan, S.; Kumar, R.; Sharon, A.; Ghosh, A., Enhanced Solubility of Telmisartan Phthalic Acid Cocrystals within the pH Range of a Systemic Absorption Site. ACS Omega 2018, 3 (11), 15380-15388. DOI: https://doi.org/10.1021/acsomega.8b02144 

3. Pathare, R. S.; Patil, V.; Kaur, H.; Maurya, A. K.; Agnihotri, V. K.; Khan, S.; Devunuri, N.; Sharon, A.; Sawant, D. M., Iodine-Catalyzed Cross-Coupling of Isocyanides and Thiols for the synthesis of S-Thiocarbamates. Organic & Biomolecular Chemistry(RSC) 2018, 16, 6885-6888. DOI: https://doi.org/10.1039/C8OB01855C 

4. Pathare, R. S.; Ansari, A. J.; Verma, S.; Maurya, A.; Maurya, A. K.; Agnihotri, V. K.; Sharon, A.; Pardasani, R. T.; Sawant, D. M., Sequential Pd(0)/Fe(III) Catalyzed Azide–Isocyanide Coupling/Cyclization Reaction: One-Pot Synthesis of Aminotetrazoles. The Journal of Organic Chemistry (ACS) 2018, 83 (16), 9530-9537. DOI: https://doi.org/10.1021/acs.joc.8b01261

• 2016

1. Mohan Kasula, M.; Toyama, M.; Samunuri, R.; Rozy, F.; Yadav, M.; Bal, C. Jha, A. K.; Baba, M.; Sharon, A.; Synthesis and anti-HBV activity of α-stereoisomer of aristeromycin based analogs Bioorg. Med. Chem. Letts. 2016, 3945-9.

2. Thiyagarajan, A.; Toyama, M.; Baba, M. Sharon, A.; Bal, C. Synthesis and Anti-HCV Activity of 4-Methoxy-7H-Pyrrolo[2,3-d] Pyrimidine Carbocyclic. Nucleosides, Nucleotides and Nucleic Acids, 2016, 35, 305-14.

3. Kasula, M., Samunuri, R.; Chakravarty, H.; Bal, C.; Baba, M.; Jha, A. K.; Sharon, A.; Regioselective synthesis of pyrazolo[3,4-d]pyrimidine based carbocyclic nucleosides as possible antiviral agent. Nucleosides, Nucleotides and Nucleic Acids, 2016, 35, 43-52.

4. Pathare, R. S.; Sharma, S.; Elagandhula, S.; Saini, V.; Sawant, D. M.; Yadav, M.; Sharon, A.; Khan, S.; Pardasani, R. T., Application of Isocyanides as Amide Surrogates in the Synthesis of Diverse Isoindolin-1-one Derivatives by a Palladium-Catalyzed Tandem Carboxamidation/Hydroamidation Reaction. European Journal of Organic Chemistry 2016, 5579-87.

• 2015

1. Balaraju, T.; Konreddy, A. K.; Parveen, A.; Toyama, M.; Ito, W.; Karampuri, S.; Baba, M.; Sharon, A.; Bal, C., Synthesis and anti-HCV determinant motif identification in pyranone carboxamide scaffold. Bioorganic & Medicinal Chemistry Letters 2015, 25 (22), 5224-7. 

2. Chakravarty, H.; Ojha, D.; Konreddy, A. K.; Bal, C.; Chandra, N. S.; Sharon, A.; Chattopadhyay, D., Synthesis of multi ring-fused imidazo [1,2-a]isoquinoline-based fluorescent scaffold as anti-Herpetic agent. Antiviral Chemistry and Chemotherapy 2015, 24 (5-6), 127-135

3. Bal, N. C.; Jena, N.; Chakravarty, H.; Kumar, A.; Chi, M.; Balaraju, T.; Rawale, S. V.; Rawale, J. S.; Sharon, A.; Periasamy, M., The C-terminal calcium-sensitive disordered motifs regulate isoform-specific polymerization characteristics of calsequestrin. Biopolymers 2015, 103 (1), 15-22.

4. Chaudhary, S.; Sharma, V.; Jaiswal, P. K.; Gaikwad, A. N.; Sinha, S. K.; Puri, S. K.; Sharon, A.; Maulik, P. R.; Chaturvedi, V., Stable Tricyclic Antitubercular Ozonides Derived from Artemisinin. Organic Letters 2015, 17 (20), 4948-51.

• 2014

1. Karampuri, S., Ojha, D., Bag, P., Chakravarty, H., Bal, C., Chattopadhyay, D. & Sharon, A. (2014). Anti-HSV activity and mode of action study of α-pyrone carboxamides. RSC Advances: http://dx.doi.org/10.1039/C4RA01303D

2. Konreddy, A. K.; Toyama, M.; Ito, W.; Bal, C.; Baba, M.; Sharon, A., Synthesis and Anti-HCV Activity of 4-Hydroxyamino α-Pyranone Carboxamide Analogues. ACS Medicinal Chemistry Letters 2014, 5 (3), 259-263 .http://dx.doi.org/10.1021/ml400432f

3. Bag, P.; Ojha, D.; Mukherjee, H.; Halder, U. C.; Mondal, S.; Biswas, A.; Sharon, A.; Van Kaer, L.; Chakrabarty, S.; Das, G.; Mitra, D.; Chattopadhyay, D., A dihydro-pyrido-indole potently inhibits HSV-1 infection by interfering the viral immediate early transcriptional events. Antiviral Research 2014, 105, 126-34. http://dx.doi.org/10.1016/j.antiviral.2014.02.007

4. Singh, S.; Yadav, P.; Sahu, S. N.; Sharon, A.; Kumar, B.; Ram, V. J.; Pratap, R., One-Pot Chemoselective Synthesis of Arylated Benzo[h]quinolines. Synlett 2014, 25 (18), 2599-2604.

5. 2013

6. Bag, P.; Ojha, D.; Mukherjee, H.; Halder, U. C.; Mondal, S.; Chandra, N. S.; Nandi, S.; Sharon, A.; Sarkar, M. C.; Chakrabarti, S.; Chattopadhyay, D., An indole alkaloid from a tribal folklore inhibits immediate early event in HSV-2 infected cells with therapeutic efficacy in vaginally infected mice. PloS one 2013, 8 (10), e77937.

7. A. Parveen, A. Chakraborty, A. K. Konreddy, H. Chakravarty, A. Sharon, V. Trivedi, C. Bal Skeletal hybridization and PfRIO-2 kinase modeling for synthesis of a-pyrone analogs as anti-malarial agent. Eur. J. Med. Chem., (2013) 607-612.http://dx.doi.org/10.1016/j.ejmech.2013.10.028

8. M. Kasula, B. Tuniki, M. Toyama, A. Thiyagarajan, C. Bal, M. Baba, A. Sharon: Conformational Mimetic Approach for Synthesis of New Carbocyclic Nucleosides as Anti-HCV Lead" ChemMedChem, 2013, 8, 1673-1680. http://dx.doi.org/10.1002/cmdc.201300277

9. M. Karak, N.C. Bal, C. Bal, A. Sharon, Targeting peroxisome proliferator-activated receptor gamma for generation of antidiabetic drug, Curr Diabetes Rev, 9 (2013) 275-285. http://dx.doi.org/10.2174/15733998113099990065

10. A. Kumar, H. Chakravarty, N.C. Bal, T. Balaraju, N. Jena, G. Misra, C. Bal, E. Pieroni, M. Periasamy, A. Sharon, Identification of calcium binding sites on calsequestrin 1 and their implications for polymerization, Molecular BioSystems, 9 (2013) 1949-1957. http://dx.doi.org/10.1039/c3mb25588c

11. D. Chouhan, A. Sharon, C. Bal, Molecular and structural insight into plasmodium falciparum RIO2 kinase, Journal of molecular modeling, 19 (2013) 485-496. http://dx.doi.org/10.1007/s00894-012-1572-3

12. S. Nag, D. Chouhan, S.N. Balaji, A. Chakraborty, K. Lhouvum, C. Bal, A. Sharon, V. Trivedi, Comprehensive screening of heterocyclic compound libraries to identify novel inhibitors for PfRIO-2 kinase through docking and substrate competition studies, Med Chem Res, (2013) 1-8.http://dx.doi.org/10.1007/s00044-013-0483-x

• 2012

1. Balaraju, T., Kumar, A., Bal, C., Chattopadhyay, D., Jena, N., Bal, N. C. & Sharon, A. (2012). Aromatic interaction profile to understand the molecular basis of raltegravir resistance. Structural Chemistry 2012, 1-14.: http://dx.doi.org/10.1007/s11224-012-0181-1

2. Thiyagarajan, A., Salim, M. T., Balaraju, T., Bal, C., Baba, M. & Sharon, A. (2012). Structure based medicinal chemistry approach to develop 4-methyl-7-deazaadenine carbocyclic nucleosides as anti-HCV agent. Bioorg Med Chem Lett 22, 7742-7.doi: http://dx.doi.org/10.1016/j.bmcl.2012.09.072

3. Karampuri, S., Bag, P., Yasmin, S., Chouhan, D. K., Bal, C., Mitra, D., Chattopadhyay, D. & Sharon, A. (2012). Structure based molecular design, synthesis and biological evaluation of alpha-pyrone analogs as anti-HSV agent. Bioorg Med Chem Lett 22, 6261-6. http://dx.doi.org/10.1016/j.bmcl.2012.07.098

4. Chattopadhyay, D., Mukherjee, H., Paromita Bag, Ojha, D., Konreddy, A. K., Dutta, S., Kumar, H. P., Tapan, C., Sharon, A. & Sekhar, C. (2012). Inhibition of NO2, PGE2, TNF-α, and iNOS EXpression by Shorea robusta L.: An Ethnomedicine Used for Anti-Inflammatory and Analgesic Activity. Evidence-Based Complementary and Alternative Medicine 2012, 14.

• 2011.......

1. Bal, N. C., Jena, N., Sopariwala, D., Balaraju, T., Shaikh, S., Bal, C., Sharon, A., Gyorke, S. & Periasamy, M. (2011). Probing cationic selectivity of cardiac calsequestrin and its CPVT mutants. Biochem J 435, 391-9.

2. Gadthula, S., Rawal, R. K., Sharon, A., Wu, D., Korba, B. & Chu, C. K. (2011). Synthesis and antiviral activity of cyclopropyl-spirocarbocyclic adenosine, (4R,5S,6R,7R)-4-(6-amino-9H-purin-9-yl)-7-(hydroxymethyl)spiro[2.4]heptane -5,6-diol against hepatitis C virus. Bioorg Med Chem Lett 21, 3982-5.

3. Rao, J. R., Jha, A. K., Rawal, R. K., Sharon, A., Day, C. W., Barnard, D. L., Smee, D. F. & Chu, C. K. (2010). (-)-Carbodine: enantiomeric synthesis and in vitro antiviral activity against various strains of influenza virus including H5N1 (avian influenza) and novel 2009 H1N1 (swine flu). Bioorg Med Chem Lett 20, 2601-4.

4. Kim, Y. A., Rawal, R. K., Yoo, J., Sharon, A., Jha, A. K., Chu, C. K., Rais, R. H., Al Safarjalani, O. N., Naguib, F. N. & El Kouni, M. H. (2010). Structure-activity relationships of carbocyclic 6-benzylthioinosine analogues as subversive substrates of Toxoplasma gondii adenosine kinase. Bioorg Med Chem 18, 3403-12.

5. Karuppasamy, M., Mahapatra, M., Yabanoglu, S., Ucar, G., Sinha, B. N., Basu, A., Mishra, N., Sharon, A., Kulandaivelu, U. & Jayaprakash, V. (2010). Development of selective and reversible pyrazoline based MAO-A inhibitors: Synthesis, biological evaluation and docking studies. Bioorg Med Chem 18, 1875-81.

6. Bal, N. C., Sharon, A., Gupta, S. C., Jena, N., Shaikh, S., Gyorke, S. & Periasamy, M. (2010). The catecholaminergic polymorphic ventricular tachycardia mutation R33Q disrupts the N-terminal structural motif that regulates reversible calsequestrin polymerization. J Biol Chem 285, 17188-96.